Cell BiologybioRxivPreprint
When lysosomes persist: resolving the proton-sponge paradox in nanoparticle-based intracellular delivery
Indra Van Zundert, Steven Huysecom, Thibo Iven…·Susana Rocha
This study investigates how proton-sponge polymers like PEI enable cargo release without full nanoparticle escape, resolving a long-standing debate in nanomedicine.
DOI 10.64898/2026.04.29.721565