Indra Van Zundert

When lysosomes persist: resolving the proton-sponge paradox in nanoparticle-based intracellular delivery

This study investigates how proton-sponge polymers like PEI enable cargo release without full nanoparticle escape, resolving a long-standing debate in nanomedicine.

Unveiling DNA Origami Interaction Dynamics on Living Cell Surfaces by Single Particle Tracking

This study uses single particle tracking to analyze DNA origami interaction dynamics with cancer cells, revealing ligand-specific binding and density-dependent behavior.

Beyond One-Size-Fits-All: Tumor Biology Influences Nanoparticle Behaviour in Cancer Models

This study shows that nanoparticles behave differently in various tumor models, emphasizing the need to tailor their design based on tumor biology.

Cellular Responses to Photothermal Therapy: Heat-Induced ERK Signaling and Intercellular Communication in Solid Tumors

This study examines how photothermal therapy affects ERK signaling and intercellular communication in tumor spheroids using FRET sensors and deep learning.

Nanoparticle Accumulation and Penetration in 3D Tumor Models: the Effect of Size, Shape, and Surface Charge

This study evaluates how nanoparticle size, shape, and surface charge affect their accumulation and penetration in 2D and 3D tumor models, finding that larger, negatively charged, and spherical NPs perform best.