Susana Rocha

This study investigates how loss of CCM2 disrupts endothelial force balance in cerebral cavernous malformations by analyzing molecular forces and adhesion organization.

This paper introduces tunable fibrous hydrogels to study how specific ligands direct different cell migration modes in 3D environments.

This paper provides a step-by-step protocol for synthesizing and characterizing PAAm hydrogels of varying stiffness for cell culture and mechanobiology studies.

This study investigates how proton-sponge polymers like PEI enable cargo release without full nanoparticle escape, resolving a long-standing debate in nanomedicine.

This paper introduces GEM-DDM, a method using genetically encoded nanoparticles and differential dynamic microscopy to measure cytoplasmic viscosity in living cells, showing increased viscosity in aggressive colorectal cancer cells.

The paper evaluates FRET-based vinculin tension sensors to determine optimal design parameters for measuring molecular forces in cells.

This paper introduces a 3D synthetic platform to study cancer cell invasion and drug response by modeling mechanical interactions with the extracellular matrix.

This study shows that matrix stiffness in colorectal cancer alters secreted protein expression, enhancing migration, angiogenesis, and matrix remodeling, contributing to a more aggressive cancer phenotype.

This study combines Traction Force Microscopy and Vinculin Tension Sensors to analyze how molecular tension and cellular tractions interact across different scales in focal adhesions.

This study shows that nanoparticles behave differently in various tumor models, emphasizing the need to tailor their design based on tumor biology.

This study examines how photothermal therapy affects ERK signaling and intercellular communication in tumor spheroids using FRET sensors and deep learning.

This study evaluates how nanoparticle size, shape, and surface charge affect their accumulation and penetration in 2D and 3D tumor models, finding that larger, negatively charged, and spherical NPs perform best.

This paper develops neodymium-doped nanocrystals for diffraction-limited, in vitro temperature sensing with high sensitivity and biocompatibility in cancer cells.

This study shows that Vegfa isoforms differentially regulate endothelial cell proliferation via PI3K signaling, independent of MAPK (ERK) activation in zebrafish.