Rina Pokhrel

This study shows TRPV4 mediates histamine receptor signaling in lymphatic endothelial cells, enhancing Ca2+ signaling and NFATc1 translocation while cytokine release occurs through distinct mechanisms.

The paper maps the chemokine-stimulated signal transduction network in monocytic cells and shows that chemotaxis emerges from a divergent signaling network that can be inhibited to block cell migration.

This study shows that targeting mGlu5 in endosomes improves analgesia by inhibiting nuclear ERK1/2 signaling and reducing neuronal excitability in pain models.