Ronald B. Postuma

Post-traumatic stress disorder and REM-sleep behavior disorder: exploring genetic associations and causal links

The paper investigates genetic and causal links between post-traumatic stress disorder and rapid-eye-movement sleep behavior disorder using polygenic risk scores, genetic correlation, and Mendelian randomization analyses.

T cell responses towards PINK1 and α-synuclein are elevated in prodromal Parkinson's disease

The paper examines T cell responses to PINK1 and α-synuclein in prodromal Parkinson's disease, finding elevated reactivity comparable to clinically diagnosed PD.

Lack of Epistatic Interaction of SNCA with APOE in Synucleinopathies

The paper investigates genetic interactions between SNCA and APOE in synucleinopathies using GWAS data and finds no significant epistatic interactions after multiple testing correction.

NPC1 variants are not associated with Parkinson's disease, REM-sleep behaviour disorder or Dementia with Lewy bodies in European cohorts.

This study examines the association of NPC1 variants with Parkinson's disease, REM-sleep behavior disorder, and dementia with Lewy bodies in European cohorts and finds no significant associations.

Genome-wide association study of REM sleep behavior disorder identifies novel loci with distinct polygenic and brain expression effects

This study identifies five RBD risk loci through genome-wide association and finds differential expression of SNCA-AS1 and SCARB2 in brain regions.

Common and rare variants in HFE are not associated with Parkinson's disease in Europeans

The paper analyzes GWAS and sequencing data to test if HFE variants are associated with Parkinson's disease in Europeans, finding no significant associations.

Multimodal phenotypic axes of Parkinson's disease

This paper integrates multimodal data from Parkinson's disease patients using similarity network fusion to identify continuous phenotypic axes that better capture patient heterogeneity than discrete biotypes.

Association of DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 with Parkinson's Disease

This study sequenced five genes in PD patients and controls, finding no significant association with Parkinson's Disease after multiple comparisons.

GBA variants in REM sleep behavior disorder: a multicenter study

This study investigates the association between GBA variants and risk for isolated REM sleep behavior disorder (iRBD) and conversion to neurodegeneration, finding higher prevalence and increased conversion rates in carriers.

Fine-mapping of SNCA in REM sleep behavior disorder and overt synucleinopathies

This study identifies SNCA risk variants specific to RBD and overt synucleinopathies, finding distinct associations and opposite effects at the 3' end of SNCA.

An MRI Atrophy Biomarker Predicts Global Prognosis in Early De Novo Parkinson's Disease

This paper identifies a brain atrophy pattern from MRI that predicts disease progression in early Parkinson's disease better than other biomarkers.

Algorithmic complexity of EEG for prognosis of neurodegeneration in idiopathic rapid eye movement behavior disorder (RBD)

The paper uses EEG algorithmic complexity metrics to predict neurodegeneration in idiopathic RBD, finding decreased complexity correlates with poor prognosis.

White Matter Hyperintensities and Cognitive Decline in de Novo Parkinson’s Disease Patients

This study finds that high baseline white matter hyperintensities (WMHs) in de novo Parkinson’s disease patients are linked to greater cognitive decline and cortical thinning compared to low WMHs or controls.

A clinical-anatomical signature of Parkinson’s Disease identified with partial least squares and magnetic resonance imaging

This study identifies a clinical-anatomical signature of Parkinson’s Disease using partial least squares and MRI, showing that atrophy patterns predict clinical progression.