This study identifies genetic associations between lysosomal genes and Parkinson's disease risk across diverse populations using GWAS and whole genome sequencing data.

npj Parkinson s Disease · Dec 2, 2025Peer-reviewedGenetic & Genomic Medicine

Lack of association between G6PD variants and Parkinson's disease

Leah V. Chifamba, Sitki Cem Parlar, Lang Liu, Leonard L. Sokol, Eric Yu, Farnaz Asayesh, Jamil Ahmad, Jennifer A. Ruskey, Dan Spiegelman, Cheryl Waters, Oury Monchi, Yves A Dauvilliers, Nicolas Dupré, Alla Timofeeva, Anton Emelyanov, , Konstantin A. Senkevich

This study investigates the association between G6PD variants and Parkinson's disease across six cohorts and finds no significant links for common or rare variants.

medRxiv · Apr 23, 2025 · PreprintGenetic & Genomic Medicine

The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons

Jace Jones-Tabah, Kathy He, Nathan C. Karpilovsky, Konstantin A. Senkevich, Ghislaine Deyab, Isabella Pietrantonio, Thomas Goiran, Yuting Cousineau, Daria Nikanorova, Taylor Goldsmith, Esther del Cid‐Pellitero, Carol X.‐Q. Chen, Wen Luo, Zhipeng You, Narges Abdian, , Edward A. Fon

This study investigates the role of cathepsin B in Parkinson's disease by analyzing genetic variants and manipulating catB function in cell models to assess its impact on lysosomal activity and alpha-synuclein clearance.

Molecular Neurodegeneration · Nov 24, 2024Peer-reviewedNeuroscience

Are rare heterozygous SYNJ1 variants associated with Parkinson's disease?

Konstantin A. Senkevich, Sitki Cem Parlar, Cloe Chantereault, Eric Yu, Jamil Ahmad, Jennifer A. Ruskey, Farnaz Asayesh, Dan Spiegelman, Cheryl Waters, Oury Monchi, Yves A Dauvilliers, Nicolas Dupré, Irina V. Miliukhina, Alla Timofeeva, Anton Emelyanov, , Ziv Gan‐Or

This study investigates the association between rare SYNJ1 variants and Parkinson's disease, finding an association with both sporadic and early-onset cases.

npj Parkinson s Disease · Oct 25, 2024Peer-reviewedGenetic & Genomic Medicine

Longitudinal brain structure changes in Parkinson's disease: a replication study

Andrzej Sokołowski, Nikhil Bhagwat, Yohan Chatelain, Mathieu Dugré, Alexandru Hanganu, Oury Monchi, Brent Caleb McPherson, Michelle Wang, Jean‐Baptiste Poline, Madeleine E. Sharp, Tristan Glatard

This study replicates findings from Hanganu et al. (2014) on Parkinson's disease neuroimaging biomarkers using PPMI data, finding partial replication of cortical thinning and cognitive decline associations.

PLoS ONE · Jan 31, 2024Peer-reviewedNeuroscience

Multi-ancestry genome-wide meta-analysis in Parkinson's disease

Jonggeol Jeffrey Kim, Dan Vitale, Diego Véliz Otani, Michelle Mulan Lian, Karl Heilbron, Stella W. Aslibekyan, Adam Auton, Elizabeth Babalola, Robert K. Bell, Jessica Bielenberg, Katarzyna Bryc, Emily Bullis, Paul Cannon, Daniella Coker, Gabriel Cuéllar-Partida, , Piu Chan

This paper conducts a multi-ancestry genome-wide meta-analysis of Parkinson's disease, identifying 78 independent loci and 23 genes associated with PD risk.

Nature Genetics · Dec 28, 2023Peer-reviewedGenetic & Genomic Medicine

Global Parkinson's Genetics Program (GP2) Complex Network Protocol: Defining the causes of sporadic Parkinson's disease

Clodagh Towns, Madeleine Richer, Simona Jasaityte, Eleanor J. Stafford, Julie Joubert, Tarek Antar, Alejandro Martínez-Carrasco, Mary B. Makarious, Bradford H. Casey, Dan Vitale, Kristin S. Levine, Hampton L. Leonard, Caroline B. Pantazis, Laurel A. Screven, Dena G. Hernandez, , Andrea Quattrone

The paper outlines the protocol for integrating genetic and clinical data from a global cohort of over 150,000 participants to study the genetic causes of sporadic Parkinson's disease.

npj Parkinson s Disease · Sep 12, 2023Peer-reviewedGenetic & Genomic Medicine

Association of DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 with Parkinson's Disease

Prabhjyot Saini, Uladzislau Rudakou, Eric Yu, Jennifer A. Ruskey, Farnaz Asayesh, Sandra B. Laurent, Dan Spiegelman, Stanley Fahn, Cheryl Waters, Oury Monchi, Yves A Dauvilliers, Nicolas Dupré, Lior Greenbaum, Sharon Hassin‐Baer, Alberto Javier Espay, , Ziv Gan‐Or

This study sequenced five genes in PD patients and controls, finding no significant association with Parkinson's Disease after multiple comparisons.

Neurobiology of Aging · Oct 31, 2020Peer-reviewedGenetic & Genomic Medicine

Consistent inter-protocol differences in resting-state functional connectomes between normal aging and mild cognitive impairment

Angela Tam, Christian Dansereau, AmanPreet Badhwar, Pierre Orban, Sylvie Belleville, Howard Chertkow, Alain Dagher, Alexandru Hanganu, Oury Monchi, Pedro Rosa-Neto, Amir Shmuel, Seqian Wang, John Breitner, Pierre Bellec, Alzheimer’s Disease Neuroimaging Initiative

The paper identifies consistent functional connectivity differences between normal aging and mild cognitive impairment across varied imaging protocols.

bioRxiv · Jul 18, 2015 · PreprintNeuroscience