Irene Litvan

Cerebrospinal fluid YWHAG:NPTX2 ratio predicts clinical severity and future phenoconversion in frontotemporal lobar degeneration

The paper identifies the CSF YWHAG:NPTX2 ratio as a biomarker for predicting clinical severity and phenoconversion in FTLD, showing strong correlation with disease progression and improved trial design potential.

T cell responses towards PINK1 and α-synuclein are elevated in prodromal Parkinson's disease

The paper examines T cell responses to PINK1 and α-synuclein in prodromal Parkinson's disease, finding elevated reactivity comparable to clinically diagnosed PD.

Differential memory enrichment of cytotoxic CD4 T cells in Parkinson's disease patients reactive to α-synuclein

The paper investigates T cell subsets in Parkinson's disease patients reactive to α-synuclein, finding reduced Granulysin+ CD4 cytotoxic TEM cells and altered CELSR2 expression.

Sex differences in the clinical manifestation of autosomal dominant frontotemporal dementia

This study examines sex differences in clinical progression of autosomal dominant frontotemporal dementia, finding females show more rapid declines in symptomatic stages and less sensitive NfL prognostic value.

Whole-Genome Sequencing Analysis Reveals New Susceptibility Loci and Structural Variants Associated with Progressive Supranuclear Palsy

This study uses whole-genome sequencing to identify new genetic loci and structural variants associated with progressive supranuclear palsy, including novel signals in APOE and H1/H2 haplotype region variants.

Chromogranin A Deficiency Attenuates Tauopathy by Altering Epinephrine Alpha-Adrenergic Receptor Signaling

This study shows that CgA deficiency reduces tau pathology and improves cognitive function in tauopathy models by modulating epinephrine-alpha-adrenergic receptor signaling.

Nicked tRNAs are stable reservoirs of tRNA halves in cells and biofluids

The paper identifies nicked tRNAs as stable extracellular RNA species in biofluids and demonstrates methods to recover full-length tRNAs from these nicked forms.

Neuropathological validation of the MDS-PSP criteria with PSP and other frontotemporal lobar degeneration

This paper validates the 2017 MDS-PSP criteria for diagnosing PSP and variant syndromes using neuropathological data, showing higher sensitivity but lower specificity compared to older criteria.