April Frazier

Durability and diversity of human upper airway T cell memory

This study longitudinally tracks antigen-specific T cells in human upper airway tissues and blood, finding sustained memory T cell populations over 18 months.

Evolution of SARS-CoV-2 T cell responses as a function of multiple COVID-19 boosters

This study examines T cell and antibody responses in vaccinated individuals over three years, finding stable T cell responses and increased regulatory T cells after multiple boosters.

T cell responses towards PINK1 and α-synuclein are elevated in prodromal Parkinson's disease

The paper examines T cell responses to PINK1 and α-synuclein in prodromal Parkinson's disease, finding elevated reactivity comparable to clinically diagnosed PD.

Differential memory enrichment of cytotoxic CD4 T cells in Parkinson's disease patients reactive to α-synuclein

The paper investigates T cell subsets in Parkinson's disease patients reactive to α-synuclein, finding reduced Granulysin+ CD4 cytotoxic TEM cells and altered CELSR2 expression.

PINK1 is a target of T cell responses in Parkinson's disease

The paper identifies PINK1 as an autoantigen targeted by T cells in Parkinson's disease, with reactivity predominantly observed in male patients.