Paradoxical increases in anterior cingulate cortex activity during nitrous oxide-induced analgesia reveal a signature of pain affect
Jarret A.P. Weinrich, Cindy D. Liu, Madison E. Jewell, Christopher R. Andolina, Mollie X. Bernstein, Jorge Benitez, Sian Rodriguez-Rosado, Joao M. Braz, Mervyn Maze, Mikhail I. Nemenov, Allan I. Basbaum
The paper shows that nitrous oxide increases anterior cingulate cortex activity in mice, suggesting this activity reflects pain affect even under anesthesia.
Pain · Aug 11, 2025Peer-reviewedNeuroscience