Marc Tessier‐Lavigne

The paper develops a human midline assembloid model to study axon guidance and identifies GALNT2 as a human-specific regulator of commissural axon guidance.

The paper shows that multiple guidance factors, including Netrin-1 and Slit proteins, are required for proper axon bifurcation in the dorsal funiculus during spinal cord development.

The paper develops a morphometric reconstruction pipeline to analyze cortical VIP/ChAT interneurons and finds insult-driven plasticity in their morphology and gene expression.

TrailMap is a 3D convolutional network that maps and quantifies axonal projections in cleared mouse brains, validated across multiple neuronal populations.

The paper shows that reduction of cerebellar nuclei neurons leads to proportional scaling down of cerebellar cortex growth due to loss of their presynaptic Purkinje cells.

The paper uses TRAP2 to study how prefrontal cortex neurons involved in memory retrieval change over time and support remote memory.

Genome-wide CRISPR-Cas9 screens in human cells reveal mechanisms and targets for ALS-associated C9orf72 dipeptide repeat protein toxicity.