Fides Lea Zenk

The paper uses single-cell and spatial multi-omic analyses to characterize cellular diversity in RTK-fused gliomas across pediatric age groups, identifying distinct cancer cell states and myeloid subgroups.

This study identifies species-specific oxygen sensing as a key factor in limb regeneration, showing that reducing oxygen sensing in amphibians enhances regenerative capacity while mammals require oxygen-sensitive pathways.

TopoTome is an unsupervised 3D image segmentation algorithm that outperforms existing methods by using topological data analysis to detect and segment structural features in biological images.

The paper uses live imaging and single-cell transcriptomics to study how extracellular matrix influences brain organoid development and regionalization.

Phospho-seq integrates phosphorylated protein profiling with scATAC-seq and scRNA-seq to study cell signaling and gene regulation in single cells.

The paper reconstructs epigenomic trajectories in human neural organoids from pluripotency to terminal cell states using single-cell histone modification profiling.

The paper uses single-cell genomic data from human cerebral organoids to infer gene regulatory networks and assess transcription factor roles in brain development.