Author

Sophia Missoury

Centre National de la Recherche ScientifiqueORCID 0000-0001-7478-6956Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:structural biology· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Organism:yeast· 1

Frequent Co-Authors

Marc H. DelarueiD· 3 shared Soizick Lucas‐StaatiD· 2 shared Ahmed HaouziD· 1 shared Amandine Pelletier· 1 shared Ana‐Andreea ArteniiD· 1 shared Antonin NourissoniD· 1 shared Bruno CollinetiD· 1 shared Carlos A. H. FernandesiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersMolecular Biology

Marc H. DelarueORCID

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4 papers

Recent·Most cited

Molecular BiologyNucleic Acids ResearchPeer-reviewedOct 24, 2026

Structural Basis for DNA Replication and Uracil Repair in Phage A-Family DNA Polymerases

Sophia Missoury, Soizick Lucas‐Staat, Rémi Sieskind, Marc H. Delarue

The paper presents cryo-EM structures of phage A-family DNA polymerases fused to a uracil-DNA glycosylase domain, revealing their role in reading dU bases and repairing abasic sites during replication.

1 citation

experimental assay

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Molecular BiologybioRxivPreprintMar 12, 2026

Structural basis for continuous DNA-end protection during ligation of double-strand breaks in yeast Non-Homologous End-Joining

Sophia Missoury, Claire Tettaravou, Sara Castelli…·Marc H. Delarue

This study presents cryo-EM structures of yeast NHEJ complexes, revealing mechanisms for DNA-end protection and ligation without DNA-PKcs.

DOI 10.64898/2026.03.12.711350

yeastexperimental assay

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BiochemistrybioRxivPreprintMar 3, 2026

Structure of the human KEOPS/tRNA complex and characterization of pathogenic variants responsible for the Galloway Mowat syndrome.

Charles Cirio, Sylvie Auxilien, Dominique Liger…·Bruno Collinet

The paper determines the structure of the human KEOPS/tRNA complex and characterizes pathogenic variants in the t6A pathway linked to Galloway-Mowat syndrome.

DOI 10.64898/2026.03.03.709218

humanstructural biology

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BiochemistryNucleic Acids ResearchPeer-reviewedJul 31, 2025

Mechanisms Ensuring Fidelity of Family X DNA Polymerases in Programmed DNA rearrangements in Paramecium tetraurelia

Antonin Nourisson, Sophia Missoury, Soizick Lucas‐Staat…·Marc H. Delarue

The paper investigates how DNA polymerases in Paramecium tetraurelia ensure high fidelity during programmed DNA rearrangements by analyzing structural changes in polymerase lambda mutants.

3 citations

structural biologyexperimental assay

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