Author

Maansi Asthana

Purdue University West LafayetteORCID 0009-0002-7545-7294Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genomics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:deep learning· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Aarthi NarayananiD· 1 shared Adam Burgess· 1 shared Adrianne L. JenneriD· 1 shared Akhil AmbekariD· 1 shared Ali Sinan SaglamiD· 1 shared Alison Bunio AlveariD· 1 shared Amber M. SmithiD· 1 shared Andreas BueckleiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperSystems Biology

Aarthi NarayananORCID

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3 papers

Recent·Most cited

A MEF2C transcription factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease

Ricardo Melo Ferreira, Debora L. Gisch, Carrie L. Phillips, Ying‐Hua Cheng, Nicholas Lucarelli, Soumya Yennapureddy, Maansi Asthana, Blue B. Lake, William S. Bowen, Fang Fang, Mahla Asghari, Angela R. Sabo, Daria Barwinska, Michael J. Ferkowicz, Robert D. Toto, , Tashas Cameron-Wheeler

This study identifies a MEF2C transcription factor network that regulates endothelial cell proliferation in diabetic kidney disease and shows that SGLT2i treatment can reverse its dysregulation.

Kidney International · Apr 27, 2026Peer-reviewedCell Biology

Attentive deep learning-based tumor-only somatic mutation classifier achieves high accuracy agnostic of tissue type and capture kit.

Robert T. McLaughlin, Maansi Asthana, Marc A. Di Meo, Michele Ceccarelli, Howard J. Jacob, David L. Masica

The paper develops a deep learning classifier to distinguish somatic and germline mutations in tumor-only samples, achieving high accuracy across tissue types and reducing racial bias in TMB estimates.

bioRxiv · Dec 7, 2021 · PreprintGenomics

Iterative community-driven development of a SARS-CoV-2 tissue simulator

Michael Getz, Yafei Wang, Gary C. An, Maansi Asthana, Andrew Becker, Chase Cockrell, Nicholson T. Collier, Morgan Craig, Courtney L. Davis, James R. Faeder, Ashlee N. Ford Versypt, Tarunendu Mapder, Juliano F. Gianlupi, James A. Glazier, Sara Hamis, , Paul Macklin

Open-source agent-based PhysiCell model of SARS-CoV-2 infection in lung epithelium; version 5 clears virus in about 6 days in simulation, and delayed T cell arrival increases epithelial loss.

bioRxiv · Apr 2, 2020 · PreprintSystems Biology✦ In-depth digest