Florian Koehler

Targeted Magnetic Nanodiscs for Wireless Causal Manipulation of Gut-Brain Circuits

This paper develops magnetic nanodiscs for wireless, cell-type specific activation of gut-brain circuits, showing they can regulate feeding behavior through hindbrain satiety circuits.

Adeno-associated viruses escort nanomaterials to specific cells and tissues

This paper demonstrates that adeno-associated viruses can be coupled to nanoparticles to deliver them specifically to target tissues, with an example of brain-targeting using AAV serotype CAP-B10.

In vivo photopharmacology enabled by multifunctional fibers

This paper develops multifunctional fibers to deliver light and photoswitchable ligands to deep brain regions in mice, enabling optogenetic control of behavior through TRPV1 activation.