Author

Scott Machen

McGovern Institute for Brain Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Emmanuel Vargas Paniagua· 3 shared Keisuke NagaoiD· 3 shared Polina AnikeevaiD· 3 shared Jacob L. BeckhamiD· 2 shared Rebecca LeomiiD· 2 shared Taylor M. CannoniD· 2 shared Cameron ForbriggeriD· 1 shared Chae Gyu LeeiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBioengineering

Emmanuel Vargas Paniagua

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Adrenal remodeling encodes stress axis memory to shape fentanyl seeking

Pema Maretich, Taylor M. Cannon, Tomer Milo, Nicole Pagane, Ethan J. Frey, Faith Choe, Emmanuel Vargas Paniagua, Rebecca Leomi, Scott Machen, Keisuke Nagao, Harikesh S. Wong, Sara L. Prescott, Kerry James Ressler, Polina Anikeeva

This study shows that fentanyl interacts with the HPA axis over different timescales, with adrenal remodeling encoding stress history to influence fentanyl-seeking behavior.

bioRxiv · Oct 25, 2026 · PreprintNeuroscience

Targeted Magnetic Nanodiscs for Wireless Causal Manipulation of Gut-Brain Circuits

Ye Ji Kim, Nasim Biglari, Taylor M. Cannon, Cameron Forbrigger, Scott Machen, Emmanuel Vargas Paniagua, Karen Ka Lam Pang, Jessica Slaughter, Jacob L. Beckham, Keisuke Nagao, Elizabeth Whittier, Florian Koehler, Rebecca Leomi, Polina Anikeeva

This paper develops magnetic nanodiscs for wireless, cell-type specific activation of gut-brain circuits, showing they can regulate feeding behavior through hindbrain satiety circuits.

bioRxiv · May 15, 2026 · PreprintBioengineering

CHARIOT-AAV: Conjugation of diverse vectors to adeno-associated viruses for delivery of large genes

Keisuke Nagao, Tatsuya Osaki, Shou Toyonaga, Chae Gyu Lee, Emmanuel Vargas Paniagua, Emily Crespin Guerra, Scott Machen, Jacob L. Beckham, Mriganka Sur, Daniel G. Anderson, Robert J. Macfarlane, Polina Anikeeva

CHARIOT-AAV conjugates diverse vectors to AAVs to enable tissue-specific delivery and expanded cargo capacity for large genes.

bioRxiv · Apr 15, 2026 · PreprintBioengineering