Zena Werb

Tumor Heterogeneity Induces Pro- and Anti-metastatic Myeloid Cell Phenotypes in Breast Cancer Lung Metastasis

The paper profiles myeloid cells in breast cancer primary tumors and metastases to show how tumor heterogeneity drives shifts in myeloid cell phenotypes from anti- to pro-metastatic.

Neoplastic immune mimicry potentiates breast tumor progression

This study identifies immune mimicry in breast cancer cells, where neoplastic cells express leukocyte receptors, enhancing tumor aggressiveness and therapy resistance.

Tumor cell-adipocyte gap junctions activate lipolysis and contribute to breast tumorigenesis

The paper shows that gap junctions between breast cancer cells and adipocytes transfer cAMP, activating lipolysis in the tumor microenvironment to support tumor growth.

MULTI-seq: Scalable sample multiplexing for single-cell RNA sequencing using lipid-tagged indices

The paper introduces MULTI-seq, a method for scalable sample multiplexing in scRNA-seq, enabling analysis of multiple tissues and perturbation experiments while improving data quality.