Kay F. Macleod

This study identifies DHHC7 as a palmitoyl transferase that modifies KRAS4A, enhancing its membrane localization and activation, and shows that targeting DHHC7 inhibits pancreatic tumor growth.

This study shows that pancreatic cancer cells in a nutrient-stressed tumor microenvironment develop drug tolerance, and identifies BCL-XL inhibition as a potential therapeutic strategy.

The paper shows that arginine restriction in the tumor microenvironment limits lipid synthesis in pancreatic cancers, making them susceptible to polyunsaturated fatty acids via ferroptosis.

This paper introduces GBCD to decompose tumor transcriptional heterogeneity in scRNA-seq data, identifying a new prognostic gene expression program in pancreatic cancer.

This study shows that autophagy in myeloid cells can either promote or suppress tumor growth depending on the tumor context, highlighting the need for targeted autophagy inhibitors in cancer therapy.