T cell cholesterol transport is a metabolic checkpoint that links intestinal immune responses to dietary lipid absorption
Yajing Gao, John Paul Kennelly, Xiao Xu, Emily C. Whang, Alessandra Ferrari, Alexander H. Bedard, Julia J. Mack, Alexander Nguyen, Sonal Srikanth, Thomas A. Weston, Lauren F. Uchiyama, Whitaker Cohn, Danielle H. Cho, Min Sub Lee, Julian P. Whitelegge, , Peter Tontonoz
This study identifies Aster-A as a cholesterol transporter in T cells that regulates immune signaling and metabolic responses by controlling membrane cholesterol levels.
Science · Oct 9, 2025Peer-reviewedPhysiology