Honorine Destain

This study shows that negative autoregulation of the TF UNC-3 maintains precise expression levels in post-mitotic neurons, counterbalanced by positive input from CEH-20/PBX, ensuring cell identity.

The paper identifies both cell-autonomous and non-cell-autonomous roles of UNC-3 in C. elegans motor neurons, revealing its impact on neuronal identity and downstream connectivity.

This study identifies transcription factor feedback loops that maintain and restore touch sensation in C. elegans by securing interneuron identity and function.

This study identifies discrete intermediates in mouse meiosis crossover formation and shows distinct genetic roles for MLH3 in intermediate differentiation.

The paper shows that Hox proteins maintain neurotransmitter identity in C. elegans motor neurons through a homeostatic mechanism involving a positive feedforward loop and negative feedback.