Author

Laura A. Orofiamma

Toronto Metropolitan UniversityORCID 0000-0002-6596-4754Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Laura A. Orofiamma1 paper · Western University

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Ayshin MehrabiiD· 2 shared Costin N. AntonescuiD· 2 shared Aesha Dharmesh Patel· 1 shared Alyona IvanovaiD· 1 shared Anne‐Claude GingrasiD· 1 shared Colin D.H. RatcliffeiD· 1 shared Eden FussneriD· 1 shared Farnaz Fekri· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCell Biology

Ayshin MehrabiORCID

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2 papers

Recent·Most cited

AMPK Repositions Early Endosomes via Gapex-5 to Promote Delivery of Iron to Mitochondria

Ayshin Mehrabi, Laura A. Orofiamma, Alyona Ivanova, Kale Allison, Natalie Uzynski, Maria Narciso, Roberto J. Botelho, Eden Fussner, Costin N. Antonescu

This study shows AMPK moves early endosomes to mitochondria via Gapex-5 to enhance iron delivery under nutrient scarcity.

bioRxiv · Oct 26, 2025 · PreprintCell Biology

Cargo-selective regulation of clathrin-mediated endocytosis by AMP-activated protein kinase

Laura A. Orofiamma, Ralph Christian Delos Santos, Ayshin Mehrabi, Nikol Leshchyshyn, Geoffrey G. Hesketh, Sadia Rahmani, Aesha Dharmesh Patel, Farnaz Fekri, Rehman Ata, Colin D.H. Ratcliffe, Mathieu J. F. Crupi, Lois M. Mulligan, Morag Park, Anne‐Claude Gingras, Costin N. Antonescu

This study shows AMPK regulates clathrin-mediated endocytosis by controlling Dab2 and Arf6 to selectively internalize β1-integrin.

iScience · Jul 17, 2025Peer-reviewedCell Biology