Author

Chow‐Seng Kong

University of WarwickORCID 0009-0007-3446-9228Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Pathology· 1 Physiology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

Emma S. LucasiD· 4 shared Jan Joris BrosensiD· 4 shared Paul J. BrightoniD· 4 shared Joanne MuteriD· 3 shared Pavle VrljicakiD· 3 shared Hiroyuki YoshiharaiD· 2 shared Mireia Taus NebotiD· 2 shared Sascha OttiD· 2 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersPathology

Emma S. LucasORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Whole slide image analysis of the endometrial decidual reaction reveals multiscale perturbations associated with miscarriage

George Wright, Thomas M. Rawlings, Mark Eastwood, Paul J. Brighton, Mireia Taus Nebot, Anja Estermann, William T.M. Flett, Awais Younis, Komal Makwana, Hiroyuki Yoshihara, John Aplin, Chow‐Seng Kong, Mark Christian, Emma S. Lucas, Joanne Muter, , Fayyaz Minhas

The paper develops a deep learning tool to analyze endometrial histology and identifies morphological correlates of miscarriage risk.

bioRxiv · May 29, 2026 · PreprintPathology

Stalling of the endometrial decidual reaction determines the recurrence risk of miscarriage

Joanne Muter, Chow‐Seng Kong, Mireia Taus Nebot, Maria Tryfonos, Pavle Vrljicak, Paul J. Brighton, Danai Bagkou Dimakou, Megan Vickers, Hiroyuki Yoshihara, Sascha Ott, Bee Kang Tan, Phillip R. Bennett, Siobhan M. Quenby, Alex G Richter, H. Van de Velde, , Jan Joris Brosens

The frequency of menstrual cycles with a suboptimal decidual reaction determines the recurrence risk of miscarriage.

Science Advances · Jun 25, 2025Peer-reviewedPhysiology

Spatial targeting of the prostaglandin receptor EP2 to very early endosomes co-ordinates PGE2-mediated cAMP signaling in decidualizing human endometrium

Paul J. Brighton, Abigail R. Walker, Oliver Mann, Chow‐Seng Kong, Emma S. Lucas, Pavle Vrljicak, Jan Joris Brosens, Aylin Carla Hanyaloglu

The paper shows that PGE2's spatial targeting to very early endosomes is crucial for coordinating cAMP signaling in decidualizing human endometrium.

iScience · Oct 30, 2024Peer-reviewedCell Biology

Recurrent pregnancy loss is associated with a pro-senescent decidual response during the peri-implantation window

Emma S. Lucas, Pavle Vrljicak, Joanne Muter, Maria Diniz-da-Costa, Paul J. Brighton, Chow‐Seng Kong, Julia Lipecki, Katherine J. Fishwick, Joshua Odendaal, Lauren Jade Ewington, Siobhan M. Quenby, Sascha Ott, Jan Joris Brosens

The paper links a pro-senescent decidual response during the peri-implantation window to recurrent pregnancy loss, showing that immune surveillance failure leads to progesterone-resistant cells and increased miscarriage risk.

Communications Biology · Jan 21, 2020Peer-reviewedSystems Biology