Jeremy B. Foote

Oral PDE10 inhibitor ADT-030 curbed KRAS-mutant pancreatic cancer growth and metastasis in mouse models, stayed active in KRAS-inhibitor-resistant cells, and shifted tumor immune profiles.

This study evaluates two RSV-vectored SARS-CoV-2 vaccines, showing they induce systemic and mucosal immunity and protect against viral challenge and natural infection.

The paper shows IRF1 regulates B cell fate by modulating the IRF4-IRF8 axis, promoting pathogenic effector B cells in SLE.

ProAgio, an integrin αvβ3-targeted cytotoxin, enhances GPH therapy in PDAC by modulating the tumor microenvironment and improving immune responses.

This study shows that bleomycin-exposed ferrets develop sustained pulmonary fibrosis, restrictive lung physiology, and airway remodeling similar to human IPF.

This study shows that intranasal delivery of influenza antigens via a replication-deficient adenovirus induces broader antibody responses and better viral immunity in the respiratory tract compared to systemic delivery.

ADT-1004, a pan-RAS inhibitor, shows strong antitumor activity in pancreatic ductal adenocarcinoma models with high selectivity and tolerable dosing.

This study develops a mouse model of ZTTK syndrome by creating Son haploinsufficiency mice, revealing critical roles of SON in organ development and hematopoiesis.

This study evaluates the safety of continuous UV-A lighting during surgery, finding it does not cause significant DNA damage and exposes personnel to safe irradiance levels.

This study shows that Atxn10 is essential for embryonic heart development and adult kidney and pancreas function, with loss leading to lethality and epithelial to mesenchymal transition.