Author

Nicholas J. Harmer

University of ExeterORCID 0000-0002-4073-0505Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:C. elegans· 2 Organism:E. coli· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Michail N. IsupoviD· 3 shared Christopher H. Jenkins· 2 shared Isobel H. NorvilleiD· 2 shared William S. StuartiD· 2 shared Adam MonieriD· 1 shared Adrian John MulhollandiD· 1 shared Andrew F. CadzowiD· 1 shared Benjamin H. MeyeriD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersBiochemistry

Michail N. IsupovORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cryo-EM reveals multiple mechanisms of ribosome inhibition by doxycycline

William S. Stuart, Michail N. Isupov, Mathew McLaren, Christopher H. Jenkins, Adam Monier, Bertram Daum, Isobel H. Norville, Vicki A. M. Gold, Nicholas J. Harmer

This study uses cryo-EM to show doxycycline binds to the ribosome exit tunnel in C. burnetii and E. coli, revealing new mechanisms of ribosome inhibition.

Nature Communications · Jun 1, 2026Peer-reviewedBiochemistry

Establishment of an efficient one-step enzymatic synthesis of cyclic-2,3-diphosphoglycerate

Christina Stracke, Benjamin H. Meyer, Simone Antonio De Rose, Erica Elisa Ferrandi, Ilya V. Kublanov, Michail N. Isupov, Nicholas J. Harmer, Daniela Monti, Jennifer Ann Littlechild, Felix Christoph Müller, Jacky L. Snoep, Christopher Bräsen, Bettina Siebers

This paper develops an efficient one-step enzymatic method to synthesize cyclic-2,3-diphosphoglycerate using MfcDPGS from Methanothermus fervidus, achieving high conversion efficiency and scalability.

Frontiers in Microbiology · May 21, 2025Peer-reviewedBioengineering

Structure and catalytic mechanism of methylisocitrate lyase, a potential drug target against Coxiella burnetii

William S. Stuart, Christopher H. Jenkins, Philip M. Ireland, Michail N. Isupov, Isobel H. Norville, Nicholas J. Harmer

This study investigates the catalytic mechanism of methylisocitrate lyase in Coxiella burnetii, identifying key residues and structural changes involved in its function.

Journal of Biological Chemistry · Apr 16, 2025Peer-reviewedBiochemistry

Electrostatic interactions define nacubactam potency against OXA-48-like β-lactamases

Joseph F. Hoff, Kirsty E. Goudar, Karina Calvopiña, Michael Beer, Philip Hinchliffe, John M. Shaw, Catherine L. Tooke, Yuiko Takebayashi, Andrew F. Cadzow, Nicholas J. Harmer, Adrian John Mulholland, Christopher John Schofield, JAMES M. SPENCER

This paper compares the potency of nacubactam and avibactam against OXA-48-like β-lactamases, finding that nacubactam is less potent due to electrostatic repulsion with Arg214.

RSC Medicinal Chemistry · Jan 1, 2025Peer-reviewedBiochemistry