RABV L protein plays a role in immune escape through its methyltransferase activity
Marilys Castet, Wahiba Aouadi, Lauriane Kergoat, Ambre Bulteau, Rachel Legendre, Rania Ouazahrou, Lena Feige, Hugo Varet, Aurore Attina, Christophe Hirtz, Alexandre David, Étienne Decroly, Hervé Bourhy, Florence Larrous
This study shows that the K-D-K-E motif in RABV L protein's methyltransferase domain is crucial for immune evasion by altering viral and host RNA methylation, increasing sensitivity to interferon, and reducing pathogenicity.
bioRxiv · Sep 12, 2025 · PreprintMicrobiology