Étienne Decroly

A 10-year longitudinal study reveals bat-driven SARSr-CoV evolution

This study tracks SARSr-CoV evolution in Rhinolophus bats over 10 years, revealing host factors driving viral diversification and adaptation.

Nuclear activities and interactome of the NS5 protein of Tick-Borne Encephalitis Virus

This study identifies the nuclear localization and interactome of TBEV NS5 protein, revealing its role in modulating viral replication through interactions with nuclear factors.

Direct interaction between RSV polymerase L and active Rab11a mediates viral ribonucleoprotein transport to assembly sites

This study identifies RSV polymerase L as the key mediator of Rab11a interaction, revealing a molecular mechanism for vRNP transport and suggesting therapeutic targets.

Three phylogenetic metrics are compatible with natural evolution of the earliest SARS-CoV-2 sequence

The paper develops a method to detect recombination breakpoints and signs of human-made manipulation in viral sequences, finding no evidence of such manipulation in SARS-CoV-1, MERS-CoV, or SARS-CoV-2.

Crystallographic characterisation and development of bi-substrate inhibitors of coronavirus nsp14 methyltransferase

The paper develops bi-substrate inhibitors of SARS-CoV-2 nsp14 methyltransferase using structure-guided design, achieving nanomolar potency but limited cellular antiviral activity.

Can Plitidepsin Be Used as an Antiviral Against RSV?

This study investigates plitidepsin's antiviral potential against HRSV, finding it inhibits replication but also causes cellular translation inhibition and eEF1A degradation, suggesting risks for antiviral use.

RABV L protein plays a role in immune escape through its methyltransferase activity

This study shows that the K-D-K-E motif in RABV L protein's methyltransferase domain is crucial for immune evasion by altering viral and host RNA methylation, increasing sensitivity to interferon, and reducing pathogenicity.

Structure-function analysis of the nsp14 N7-guanine methyltransferase reveals an essential role in Betacoronavirus replication

This study identifies critical residues in the nsp14 N7-MTase domain essential for betacoronavirus replication and suggests potential drug targets.

Identification of a Nidovirales Orf1a N7-guanine cap methyltransferase signature-sequence as a genetic marker of large RNA genome Tobaniviridae

The paper identifies a Rossman fold N7-guanine cap methyltransferase in the Orf1a of Tobaniviridae, suggesting a genetic marker for this viral family.