Author

Doreen Manuela Floss

Düsseldorf University HospitalORCID 0000-0002-6675-5313Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Organism:mouse· 1

Frequent Co-Authors

Afshin Iram· 1 shared Anfei HuangiD· 1 shared Aparna Vaidya· 1 shared Björn StorkiD· 1 shared Constanze WiekiD· 1 shared Helmut HanenbergiD· 1 shared Holger GohlkeiD· 1 shared Isabell Lehmkuhl· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Afshin Iram

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, Mohammad Reza Ahmadian, Björn Stork, Doreen Manuela Floss, Roland P. Piekorz

This study shows SIRT4 promotes autophagy by modulating ULK1 phosphorylation, independent of HDAC6 and OPA1, and identifies its role in early autophagy initiation.

FEBS Open Bio · Nov 20, 2025Peer-reviewedBiochemistry

The mycotoxin Beauvericin is an uncompetitive inhibitor of Cathepsin B

Xiaoli Yang, Pablo Cea‐Medina, Mohanraj Gopalswamy, Aparna Vaidya, Sonja Schavier, Shixin Oltzen, Sofie Moßner, Anfei Huang, Jing Qi, Johanna Maria Hölken, Nicole Elisabeth Teusch, Doreen Manuela Floss, Markus Uhrberg, Holger Gohlke, Stefanie Scheu

This study identifies Beauvericin as an uncompetitive inhibitor of Cathepsin B through NMR, enzyme kinetics, and molecular docking analyses in dendritic cells.

Protein Science · May 24, 2025Peer-reviewedBiochemistry