Raymond F. Schinazi

The paper maps DNA-embedded ribonucleotides (rNMPs) across human cell types, revealing their non-random distribution and role as a novel epigenetic mark affecting gene expression.

This study evaluates DFMA's antiviral efficacy against multiple coronaviruses in vitro and in vivo, showing significant reductions in viral load and inflammation across different models.

This paper identifies the mechanism of resistance to the HIV-1 integrase inhibitor pirmitegravir and develops a more potent analog to overcome this resistance.

This paper develops AORBs, a high-throughput human airway organoid system, to robustly assess antiviral efficacy against SARS-CoV-2 with high throughput and clinical relevance.

The paper identifies a disproportionate incorporation of adenosine in mitochondrial and chloroplast DNA of Chlamydomonas reinhardtii compared to nuclear DNA, linked to elevated ATP levels.

The paper uses molecular dynamics simulations to study HBV capsid assembly modulators, identifying structures that predict assembly outcomes and discovering compounds with anti-viral activity.