Author

Alessandro Barberis

University of OxfordORCID 0000-0002-6718-855XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Organism:human· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Research Focus:benchmarking· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2

Frequent Co-Authors

Francesca Meteora BuffaiD· 3 shared Adrian Llewellyn HarrisiD· 1 shared Alistair EastoniD· 1 shared Ana MiariD· 1 shared Andrea TangherloniiD· 1 shared Andrew DhawaniD· 1 shared Ashwin JainarayananiD· 1 shared Ashwin M. NandakumariD· 1 shared

Activity by Year

2017-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersBioinformatics

Francesca Meteora BuffaORCID

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Author profile →

5 papers

Recent·Most cited

Suppression of de novo lipogenesis and dietary PUFA supplementation inhibit prostate cancer progression

Silvia Daniele Rodrigues, Caroline F. Ribeiro, Giuseppe Nicolò Fanelli, Isadora Ferrari Teixeira, Alessandro Barberis, Hubert Pakula, Pier Vitale Nuzzo, Filippo Pederzoli, Fabio Socciarelli, Sara Bleve, Jeanne Jiang, Jonas Dehairs, Guilherme Henrique Tamarindo, Giorgia Zadra, Lisa M. Butler, , Massimo F. Loda

This study shows that inhibiting de novo lipogenesis and supplementing with PUFAs suppresses prostate cancer progression by inducing oxidative stress and cell death.

bioRxiv · Sep 21, 2026 · PreprintCancer Biology

pysigscore: gene signatures scoring across bulk and single-cell transcriptomics

Tommaso Giacomello, Saveria Mazzara, Gennaro Abbruzzese, Alessandro Barberis, Andrea Tangherloni, Francesca Meteora Buffa

pysigscore scores gene signatures in bulk and single-cell RNA-seq data, validating its performance on multiple datasets.

bioRxiv · Aug 9, 2026 · PreprintBioinformatics

IGFs regulate cancer cell immune evasion in prostate cancer

Ashwin M. Nandakumar, Alessandro Barberis, Jin-Seon Kim, Cameron R. Lang, Jack V. Mills, Guillaume Rieunier, Dimitrios Doultsinos, Avigail Taylor, Ashwin Jainarayanan, Su Myat Phyu, Leticia Campo, Alistair Easton, Eileen E. Parkes, Timothy James, Freddie Charles Hamdy, , Valentine M. Macaulay

This study shows IGF-1 suppresses immune-related pathways in prostate cancer cells, reducing antigen presentation and increasing PD-L1, which may explain poor immunotherapy response.

Scientific Reports · Nov 3, 2025Peer-reviewedCancer Biology

Reconstructing the functional effect of TP53 somatic mutations on its regulon using causal signalling network modelling

Charalampos P. Triantafyllidis, Alessandro Barberis, Ana Miar, Enio Gjerga, Philip Vincent Charlton, Fiona Hartley, Linda van Bijsterveldt, Julio Sáez-Rodríguez, Francesca Meteora Buffa

The paper uses network modeling to analyze how TP53 mutations affect gene regulation across cancer types and samples.

bioRxiv · Jun 23, 2022 · PreprintCancer Biology

sigQC: A procedural approach for standardising the evaluation of gene signatures

Andrew Dhawan, Alessandro Barberis, Wei‐Chen Cheng, Enric Domingo, Catharine West, Tim Maughan, Jacob G. Scott, Adrian Llewellyn Harris, Francesca Meteora Buffa

This paper introduces sigQC, an R package that standardizes gene signature quality control, demonstrating its application in evaluating signatures on cancer gene expression data.

bioRxiv · Nov 13, 2017 · PreprintBioinformatics