Jonas Dehairs

Suppression of de novo lipogenesis and dietary PUFA supplementation inhibit prostate cancer progression

This study shows that inhibiting de novo lipogenesis and supplementing with PUFAs suppresses prostate cancer progression by inducing oxidative stress and cell death.

Microglial lipid signaling drives glioblastoma invasion and represents a therapeutic vulnerability

This study identifies a lipid-mediated signaling pathway driven by microglia that promotes glioblastoma invasion and shows that targeting this pathway can suppress tumor invasion.

LipidQMap - An Open-Source Tool for Quantitative Mass Spectrometry Imaging of Lipids

LipidQMap is an open-source tool for processing quantitative mass spectrometry imaging lipidomics data, enabling accurate and reproducible spatial lipid quantification across MSI platforms.

TamL is a key player of the outer membrane homeostasis in Bacteroidetes.

This study identifies TamL as essential for outer membrane integrity in Bacteroidetes, showing its role in maintaining membrane stability and interacting with TamB.

ELOVL6 as a Therapeutic Target: Disrupting c-MYC-Driven Lipid Metabolism to Enhance Chemotherapy in Pancreatic Cancer

This study identifies ELOVL6 as a therapeutic target in pancreatic cancer by showing its role in c-MYC-driven lipid metabolism and its impact on chemotherapy efficacy.

Cis-vaccenic acid is a key product of stearoyl-CoA desaturase 1 and a critical oncogenic factor in prostate cancer

This study identifies cis-vaccenic acid as a critical oncogenic factor in prostate cancer, showing it rescues cell viability loss from SCD1 inhibition and promotes growth.

Defective Schwann cell lipid metabolism alters plasma membrane dynamics in Charcot-Marie-Tooth disease 1A

This study identifies defective lipid metabolism in Schwann cells as a cause of CMT1A, showing altered lipid composition and membrane dynamics in mouse models and human iPSC-derived cells.

Extracellular vesicle-associated cholesterol dictates the regenerative functions of macrophages in the brain

This study shows that cholesterol in extracellular vesicles from repair macrophages enhances remyelination by promoting oligodendrocyte precursor cell differentiation.