Ingo Roeder

Predicting treatment-free remission outcomes in Chronic Myeloid Leukemia patients using an integrated model of tumor-immune dynamics

This paper develops a model integrating tumor-immune dynamics to predict treatment-free remission in CML patients using time-course data on NK cells and tumor load.

Tissue-scale dynamic mapping of Hematopoietic Stem Cells and supportive niche cells in the fetal liver

The paper maps the dynamic interactions between hematopoietic stem cells and niche cells in the fetal liver using multi-omics approaches, revealing spatial and temporal changes in the microenvironment.

linus: Conveniently explore, share and present large-scale biological trajectory data from a web browser.

linus provides an interactive web-based tool for exploring and sharing large-scale biological trajectory data.

TraCurate: efficiently curating cell tracks

TraCurate curates and annotates cell tracking data from time-lapse microscopy, improving accuracy with minimal user input.

Inferring immunological control mechanisms from TKI dose alterations in CML patients

The paper uses a mathematical model to classify CML patients based on immune response dynamics following TKI dose alterations, identifying different mechanisms for achieving treatment-free remission.

To cure or not to cure: consequences of immunological interactions in CML treatment

This study uses ODE models to analyze immune-leukemia interactions in CML treatment, showing that qualitative criteria outperform quantitative ones in identifying biologically relevant models.

Single Cell Phenotyping Reveals Heterogeneity among Haematopoietic Stem Cells Following Infection

The paper uses single-cell tracking to show that HSCs from infected mice exhibit heterogeneous movement patterns compared to controls, with increased persistence possibly aiding survival in altered niche environments.

Pan-embryo cell dynamics of germlayer formation in zebrafish

The paper analyzes cell dynamics across all three germlayers in zebrafish gastrulation, showing that cell movement is position-dependent rather than germlayer-specific.