Jan Huisken

The paper shows how instructive inputs during a critical period shape neural circuits to enable effective credit assignment in learning.

The paper develops a toolkit of membrane-localising tags tested across ten animal species to identify effective signals for targeting proteins to the plasma membrane.

CochleaNet is a deep learning framework for analyzing cochlea imaging data, enabling segmentation and analysis of cochlear structures and gene therapy products.

This paper introduces a high-speed light sheet microscope with isotropic sub-micron resolution for cleared tissue imaging, achieving 850 nm resolution across 1 cm3 samples.

Leonardo corrects sample-induced artifacts in light sheet microscopy images using two modules, validated on diverse biological samples.

The paper introduces T-CLEARE, a community-driven repository for tissue-clearing protocols to address replication challenges and improve protocol sharing and evaluation.

This paper uses CNNs to restore deep-tissue contrast in GFP-based time-lapse imaging using infrared dye data, improving information content across developmental stages.

This study shows KLC4 is essential for axon branching and arborization in zebrafish sensory neurons and links it to anxiety-like behavior in adults.

linus provides an interactive web-based tool for exploring and sharing large-scale biological trajectory data.

This study identifies Hand2 as a key regulator of mesothelium progenitors in zebrafish and shows its reactivation in mesothelioma, linking developmental processes to disease.

This study shows that differentiated zebrafish muscle cells can be reprogrammed into endoderm-like cells in vivo through Sox32 and Oct4 co-expression, challenging previous assumptions about lineage restriction.

The paper describes the discovery of transient NO-containing spherical structures in zebrafish cerebral endothelial cells during development, showing their dependence on Notch signaling.

The paper identifies a conserved regulatory program driving lateral plate mesoderm emergence across chordates using zebrafish and comparative analysis.

The paper presents a multi-sample imaging, processing, and analysis platform for studying vascular growth in zebrafish over time.

This study shows that basal extrusion drives tumor cell invasion and mechanical shedding of E-cadherin in zebrafish epidermis, with KRas mutations increasing invasion rates and p53 mutations enabling survival at distant sites.

This study tracks zebrafish heart development and shows that the ventricle forms continuously from progenitor cells, with FGF signaling playing a critical role in this process.

The paper traces neuromesodermal progenitors in zebrafish embryos to show they contribute to spinal cord and mesoderm with distinct growth dynamics across species.

This study uses a transparent zebrafish model to track human cancer cell dissemination in real time, revealing differences in metastatic behavior between leukemic and breast cancer cells.

The paper analyzes cell dynamics across all three germlayers in zebrafish gastrulation, showing that cell movement is position-dependent rather than germlayer-specific.