Kerim Anlaş

Metabolic control of germ layer proportions through regulation of Nodal and Wnt signalling

The paper shows that glycolytic activity regulates germ layer proportions by modulating Nodal and Wnt signalling in mouse gastrulation.

Axial patterning of gastruloids via diverse cell type compositions

This study investigates how varying proportions of primed and naive ESCs affect gastruloid formation and AP axial patterning, revealing developmental flexibility in mammalian embryogenesis.

Collective fate decisions and cell rearrangements underlie gastruloid symmetry breaking

The paper shows that collective cell fate decisions and mechanical differences drive symmetry breaking in gastruloids through a mechanochemical mechanism.

linus: Conveniently explore, share and present large-scale biological trajectory data from a web browser.

linus provides an interactive web-based tool for exploring and sharing large-scale biological trajectory data.

Dynamics of anteroposterior axis establishment in a mammalian embryo-like system

The paper studies AP axis establishment in gastruloids using scRNA-seq and identifies molecular signatures of germ layer commitment and differences between Bra/T+ and Bra/T- populations.

Self-organised symmetry breaking in zebrafish reveals feedback from morphogenesis to pattern formation

The paper shows that zebrafish embryos can break symmetry autonomously when isolated, indicating that extra-embryonic tissues are not strictly required for early patterning.

Efficient single-copy HDR by 5’ modified long dsDNA donors

The paper demonstrates that modifying the 5' ends of long dsDNA donors enhances HDR efficiency in Medaka, enabling efficient single-copy integration through monomeric donor conformation.