Author

Megan T. Zangara

Michael G. DeGroote Institute for Infectious Disease ResearchORCID 0000-0002-0884-9936Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Molecular Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

Brian K. CoombesiD· 3 shared Aline Fiebig‐ComyniD· 2 shared Michael Gordon SuretteiD· 2 shared Alexandra Fuentes· 1 shared Almer M. van der SlootiD· 1 shared Amber Hann· 1 shared András K. PontiiD· 1 shared Bushra IlyasiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersMicrobiology

Brian K. CoombesORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Phage intervention improves colitis and response to corticosteroids by attenuating virulence of Crohn's disease-associated bacteria

Kyle J. Jackson, Heather Jean Galipeau, Amber Hann, Marco Constante, Megan T. Zangara, Michael Bording‐Jorgensen, Alexandra Fuentes, Heidi Ho, Jessica Wang, Chiko Shimbori, Paul Moayyedi, Michael Gordon Surette, Přemysl Berčík, Brian K. Coombes, Zeinab Hosseinidoust, Elena Francisca Verdu

Phage HER259 reduces colitis severity caused by AIEC NRG857c and enhances budesonide efficacy in mice.

Science Translational Medicine · Jul 8, 2026Peer-reviewedMicrobiology

Peyer's patches are a niche for antibiotic-driven expansion of Crohn's disease-associated adherent-invasive Escherichia coli

Katarina R Iacobucci, Dominique Tertigas, Aline Fiebig‐Comyn, Megan T. Zangara, Michael Gordon Surette, Brian K. Coombes

This study shows antibiotic treatment increases AIEC burden in Peyers patches, leading to focal inflammation, and identifies specific AIEC traits required for niche colonization and immunopathology.

bioRxiv · May 21, 2026 · PreprintMicrobiology

A Saccharomyces boulardii synthetic biotic platform for delivery of therapeutic nanobodies to ameliorate gastrointestinal inflammation

Roger Palou, Almer M. van der Sloot, Aline Fiebig‐Comyn, Megan T. Zangara, Naseer Sangwan, María Sánchez‐Osuna, Bushra Ilyas, Haley L. Zubyk, Michael A. Cook, Gerard D. Wright, Brian K. Coombes, Mike Tyers

This paper develops a Saccharomyces boulardii platform for producing and delivering therapeutic nanobodies to treat gastrointestinal inflammation in mice.

bioRxiv · May 15, 2025 · PreprintSynthetic Biology

N-phosphonacetyl-L-aspartate enhances type I interferon anti-viral responses through activation of non-canonical NOD2 signaling

András K. Ponti, Megan T. Zangara, Christine M. O’Connor, Erin E. Johnson, Christine McDonald

This study shows that PALA enhances antiviral responses by activating non-canonical NOD2 signaling, improving type I interferon production and ISG expression.

bioRxiv · Feb 8, 2022 · PreprintMolecular Biology