Marianne L. Seney

Sex differences in cell type-specific transcriptional programs and GPCR signaling in the human subgenual anterior cingulate cortex

The paper identifies sex-specific transcriptional differences in specific cell types of the human subgenual anterior cingulate cortex and links them to GPCR signaling differences in mice.

Astrocyte molecular rhythm disruption in nucleus accumbens promotes increased binge-like drinking in mice

This study shows disrupting astrocyte molecular rhythms in the nucleus accumbens increases binge-like drinking in mice without affecting other behaviors.

Gene-specific exponent-corrected normalization for library size in bulk RNA-seq

The paper introduces gecco, a gene-specific normalization method for bulk RNA-seq that reduces library size bias while preserving biological signal, improving differential expression and pathway analysis.

Unraveling Tissue-Specific Molecular Signatures and Convergent Pathway Enrichments in Suicidal Behavior

This study identifies tissue-specific molecular signatures and convergent pathways in suicide by analyzing transcriptomic data from blood and brain tissues.

Bayesian rhythmic model for jointly detecting circadian biomarkers and predicting molecular circadian time in human post-mortem brain transcriptome

BayCT detects circadian biomarkers and estimates molecular circadian time in human brain transcriptomes, outperforming existing methods by jointly addressing both tasks.

Comparative transcriptomic rhythms in the mouse and human prefrontal cortex

This study compares circadian transcriptomic rhythms in mouse and human prefrontal cortex subregions, finding conserved signaling with sex-specific phase shifts and species-specific rhythmic transcript identities.

Peripubertal antagonism of corticotropin-releasing factor receptor 1 results in sustained changes in behavioral plasticity and the transcriptomic profile of the amygdala

This study shows that blocking CRFR1 during peripuberty alters adult behavior and amygdala gene expression in rats, with sex-specific effects.

Parvalbumin interneuron mGlu5 receptors govern sex differences in prefrontal cortex physiology and binge drinking

This study identifies mGlu1 and mGlu5 receptors as key regulators of sex differences in prefrontal cortex parvalbumin interneuron function and binge drinking behavior.

Single nuclei transcriptomics in human and non-human primate striatum implicates neuronal DNA damage and proinflammatory signaling in opioid use disorder

The paper uses single nuclei RNA-sequencing to identify striatal cell types in humans and rhesus macaques and finds molecular changes linked to opioid use disorder.

Sex differences in offspring risk and resilience following 11β-hydroxylase antagonism in a rodent model of maternal immune activation

This study investigates how metyrapone, an 11β-hydroxylase inhibitor, affects offspring behavior and corticosterone levels in a rodent model of maternal immune activation, revealing sex-specific outcomes.

Sexually dimorphic mechanisms of VGLUT-mediated protection from dopaminergic neurodegeneration

This study identifies VGLUT-mediated mechanisms protecting DA neurons from PD-related degeneration, revealing sex-specific effects and transcriptional regulators.

Circadian rhythm disruptions associated with opioid use disorder in the synaptic proteomes of the human dorsolateral prefrontal cortex and nucleus accumbens

The paper identifies synaptic protein alterations and circadian rhythm disruptions in brain regions associated with opioid use disorder using proteomics.

Sex-specific role of the circadian transcription factor NPAS2 in opioid tolerance, withdrawal, and analgesia

This study investigates the sex-specific role of NPAS2 in fentanyl-induced analgesia, tolerance, hyperalgesia, and dependence using NPAS2-deficient mice.

The ultradian transcriptome of the human prefrontal cortex and abnormalities in schizophrenia

The paper identifies 12-hour ultradian rhythms in the human prefrontal cortex and shows disruptions in schizophrenia affecting genes related to protein processing and mitochondrial function.

Molecular rhythm alterations in prefrontal cortex and nucleus accumbens associated with opioid use disorder

The paper investigates molecular rhythm alterations in the prefrontal cortex and nucleus accumbens of individuals with opioid use disorder, finding distinct rhythmic transcript patterns and associations with sleep and neurotransmitter systems.

Experimental Design and Power Calculation in Omics Circadian Rhythmicity Detection

This paper introduces CircaPower, a statistical method for power calculation in circadian rhythmicity detection, validated through simulations and real data.

Transcriptional alterations in opioid use disorder reveal an interplay between neuroinflammation and synaptic remodeling

This study identifies transcriptional changes in opioid use disorder brains, linking neuroinflammation and synaptic remodeling through RNA-seq and integrative analyses.