Vanessa M. Doulames

This paper develops a hydrogel depot system for long-acting peptide delivery, showing sustained release and improved therapeutic outcomes in rodents.

This paper develops lubricious supramolecular hydrogels to prevent peritendinous adhesions, showing improved recovery and safety in preclinical models.

This paper develops long-acting hydrogel-based depot formulations of semaglutide and tirzepatide that maintain drug levels for over 6 weeks in a rat model, showing similar efficacy to daily injections.

This paper develops a method to create 3D-printed collagen scaffolds with controlled fiber alignment patterns to guide cell orientation.

This study develops intranasal sertraline formulations to reduce systemic exposure while maintaining brain delivery, showing comparable brain exposure at half the dose compared to oral administration in mice.

This paper develops a hydrogel depot system to prolong the release of broadly neutralizing antibodies, showing improved pharmacokinetics and reduced immune cell-mediated release through co-formulation with anti-inflammatory agents.

This study transplants human induced pluripotent cell-derived deep cortical neurons into a rat spinal cord injury model, showing regeneration and improved sensorimotor function.