Author

Peter‐Christian Klöhn

MRC Prion UnitORCID 0000-0002-6850-8754Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein design· 1 Assay:protein structure· 1

Frequent Co-Authors

Christian SchmidtiD· 2 shared John CollingeiD· 2 shared Aline T. MarinhoiD· 1 shared Andrew Tomlinson· 1 shared Anthony R. ClarkeiD· 1 shared Craig A. Brown· 1 shared Craig Fitzhugh· 1 shared Elizabeth HilliD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Christian SchmidtORCID

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2 papers

Recent·Most cited

Intracellular Trafficking SNARE Protein, Syntaxin-6, is a Modifier of Prion and Tau Pathogenesis in vivo and in Cellular Models

Elizabeth Hill, Mitali Patel, Juan Manuel Ribes, Jacqueline M. Linehan, Fuquan Zhang, Michael Farmer, Tatiana Jakubcova, Shyma Hamdan, Andrew Tomlinson, Tiziana Ercolani, Christian Schmidt, Parvin Ahmed, George Thirlway, Silvia A. Purro, Fabio Argentina, , Simon Mead

This study identifies syntaxin-6 as a modifier of prion and tau pathogenesis, showing it affects disease onset but not progression in experimental models.

bioRxiv · Feb 19, 2025 · PreprintNeuroscience

Prion propagation is dependent on key amino acids in Charge cluster 2 within the prion protein

Savroop K. Bhamra, Parineeta Arora, Szymon W. Manka, Christian Schmidt, Craig A. Brown, Melissa Rayner, Peter‐Christian Klöhn, Anthony R. Clarke, John Collinge, Parmjit Jat

The paper identifies key amino acids in Charge Cluster 2 of the prion protein critical for prion propagation across multiple strains.

Journal of Molecular Biology · Dec 16, 2022Peer-reviewedMolecular Biology