Mark W. Howe

Inherited input and local transformations shape the spatiotemporal organization of pathway specific striatal signals for motivated behavior

The paper shows how striatal signals for motivated behavior are organized through inherited input and local transformations in mice.

An anatomical hotspot for striatal dopamine-acetylcholine interactions during reward and movement

The paper identifies an anatomical hotspot in the anterior dorsolateral striatum where dopamine and acetylcholine interactions are spatially organized and influence behaviorally relevant dynamics during reward and movement.

Distinct spatially organized striatum-wide acetylcholine dynamics for the learning and extinction of Pavlovian associations

This study investigates how acetylcholine dynamics in the striatum change during learning and extinction of Pavlovian associations, identifying region-specific patterns and their role in behavioral flexibility.

Dynamic imbalances in cell-type-specific striatal ensembles reflect learned coupling between trajectory representations and locomotor dynamics

The paper shows that imbalances between direct and indirect striatal pathways during locomotion are dynamic and task-dependent, linking trajectory representations to behavioral changes.

Spatially organized striatal neuromodulator release encodes trajectory errors

The paper shows that striatal dopamine and acetylcholine encode trajectory errors during navigation, with distinct spatial and temporal patterns, and links these signals to learning and behavior.

Targeted micro-fiber arrays for measuring and manipulating localized multi-scale neural dynamics over large, deep brain volumes during behavior

This paper introduces a micro-fiber array system for measuring and manipulating neural dynamics in large brain volumes during behavior, revealing spatiotemporal patterns of dopamine release and enabling precise optogenetic control.