Yizhou Zhuo

The paper introduces a genetically encoded fluorescence sensor for PKC activity, demonstrating its use in vivo and identifying PKC activity in specific neurons during locomotion.

The paper introduces a far-red dopamine sensor, HaloDA1.0, enabling multiplex imaging of neurochemical networks in vivo with high sensitivity and versatility.

The paper shows that dopamine and direct/indirect pathway neurons in the tail of the striatum regulate threat avoidance at different stages of learning.

The paper examines dopamine and acetylcholine correlations in the nucleus accumbens during a behavioral task in rats, finding their relationship varies based on task phases.

This study investigates how dopamine and acetylcholine dynamics change during learning in rats, finding that acetylcholine signals evolve sequentially and complement dopamine in determining learning content and rate.

This paper introduces a micro-fiber array system for measuring and manipulating neural dynamics in large brain volumes during behavior, revealing spatiotemporal patterns of dopamine release and enabling precise optogenetic control.

The paper identifies a glutamatergic circuit from the basal forebrain to the ventral tegmental area that reduces appetite and causes anorexia-like behaviors by decreasing dopamine release in the nucleus accumbens.

The paper develops improved GRABDA sensors to monitor dopaminergic activity in vivo, showing high sensitivity and spatially resolved DA release in mice during behaviors.

The paper investigates neuromodulator dynamics in mice during a naturalistic reward-threat task, finding distinct roles for norepinephrine, dopamine, and serotonin in encoding motivational states.

The paper develops GRAB sensors for detecting neuropeptides with high specificity and sensitivity, enabling in vivo monitoring of their release and function.

The paper develops and optimizes GRABDA fluorescent sensors to monitor dopaminergic activity with high sensitivity and resolution in vivo.