Author

Katherine R. Brimblecombe

University of OxfordORCID 0000-0003-0809-7292Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 6 Assay:electronic health records· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Stephanie Jane CraggiD· 6 shared Bradley M. RobertsiD· 5 shared Natalie Connor‐RobsoniD· 3 shared Nora Bengoa‐VergnioryiD· 3 shared Richard Wade‐MartinsiD· 3 shared Bethan O’ConnoriD· 2 shared Emanuel F. LopesiD· 2 shared Nicola J. Platt· 2 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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6 shared papersNeuroscience

Stephanie Jane CraggORCID

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6 papers

Recent·Most cited

A human GBA-L444P transgene drives early and persistent dopamine neurotransmission deficits and alpha-synuclein pathology in a mouse model of early Parkinson's disease

Natalie Connor‐Robson, Tara Diviney, Javier Alegre‐Abarrategui, Bradley M. Roberts, Katherine R. Brimblecombe, Nora Bengoa‐Vergniory, Harrison Waters, Milena Cioroch, B Luther Davies, Kateryna O. Bila, Martijn J. C. van der Lienden, Johannes M. F. G. Aerts, Stephanie Jane Cragg, Richard Wade‐Martins

This paper creates a humanised GBA-L444P mouse model to study GBA1 mutations in Parkinson's, finding gain-of-function effects on dopamine release and loss-of-function effects on alpha-synuclein pathology.

bioRxiv · May 27, 2026 · PreprintNeuroscience

An anatomical hotspot for striatal dopamine-acetylcholine interactions during reward and movement

Safa Bouabid, Mai-Anh T. Vu, Christian A. Noggle, Stefania Vietti‐Michelina, Katherine R. Brimblecombe, Nicola J. Platt, Liangzhu Zhang, Anil Joshi, Stephanie Jane Cragg, Mark W. Howe

The paper identifies an anatomical hotspot in the anterior dorsolateral striatum where dopamine and acetylcholine interactions are spatially organized and influence behaviorally relevant dynamics during reward and movement.

bioRxiv · Jan 21, 2026 · PreprintNeuroscience

Gabapentinoids promote striatal dopamine release and rescue multiple deficits of a mouse model of early Parkinson's

Katherine R. Brimblecombe, Adam Loyd Harris, Nora Bengoa‐Vergniory, Bethan O’Connor, Lucille Duquenoy, Rishi Anand, Emanuel F. Lopes, Bradley M. Roberts, Lauren M. Burgeno, Mark E. Walton, Stephanie Jane Cragg

This study shows gabapentinoids enhance dopamine release in a Parkinson's mouse model and improve movement deficits by modulating calcium and GABAergic signaling.

bioRxiv · Sep 16, 2025 · PreprintNeuroscience

Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine co-varies with risk factors for Parkinson's

Katherine R. Brimblecombe, Natalie Connor‐Robson, Carole J. R. Bataille, Bradley M. Roberts, Caitlin J. Gracie, Bethan O’Connor, Rebecca te Water Naudé, Gayathri Karthik, Angela J. Russell, Richard Wade‐Martins, Stephanie Jane Cragg

European Journal of Neuroscience · Nov 8, 2023Peer-reviewedNeuroscience

Astrocytic striatal GABA transporter activity governs dopamine release and shows maladaptive downregulation in early parkinsonism

Bradley M. Roberts, Natalie M. Doig, Katherine R. Brimblecombe, Emanuel F. Lopes, Ruth E. Siddorn, Sarah Threlfell, Natalie Connor‐Robson, Nora Bengoa‐Vergniory, Nicholas Pasternack, Richard Wade‐Martins, Peter J. Magill, Stephanie Jane Cragg

The paper investigates the role of astrocytic GABA transporters in regulating dopamine release in the striatum and shows their downregulation in early parkinsonism.

bioRxiv · Mar 7, 2020 · PreprintNeuroscience

Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter

Mark D. Condon, Nicola J. Platt, Yan-Feng Zhang, Bradley M. Roberts, Michael A. Clements, Stefania Vietti‐Michelina, Min-Yee Tseu, Katherine R. Brimblecombe, Sarah Threlfell, Edward O. Mann, Stephanie Jane Cragg

The paper investigates short-term plasticity in dopamine release in the striatum, finding that it is primarily governed by axonal properties and the dopamine transporter rather than initial release levels.

Nature Communications · Sep 19, 2019Peer-reviewedNeuroscience