CYCLOPS provides an open-source platform for cyclic multiplex imaging and single-cell phenotyping using standard microscopy infrastructure, enabling reproducible and accessible spatial proteomics.

bioRxiv · Jun 14, 2026 · PreprintCell Biology

Integrin conformation-dependent neutrophil slowing obstructs the capillaries of the pre-metastatic lung in a model of breast cancer

Frédéric Fercoq, Gemma S. Cairns, Victoria Louise Bridgeman, Marco De Donatis, John B. G. Mackey, Alessia Floerchinger, Amanda J. McFarlane, Judith Secklehner, Ximena L. Raffo Iraolagoitia, Madeline Harrington, Lynn McGarry, Demi Brownlie, Declan Whyte, Lindsey W. G. Arnott, Colin Nixon, , Leo M. Carlin

This study shows that integrin conformation-dependent neutrophil slowing in pre-metastatic lungs obstructs capillaries and may contribute to immunosuppression in breast cancer.

Cell Reports · Mar 1, 2026Peer-reviewedImmunology

Intestinal helminth skews DC2 development towards regulatory phenotype to counter the anti-helminth immune response.

Anna T. Andrusaite, Olivia J. Ridgewell, A. A. Ahlback, Holly C. Webster, Hiroki Yamaguchi, Molly Peel, Annika Frede, Sarwah Al-Khalidi, Andrew Farthing, Anna L. L. Heawood, Annabelle Smith, Edward Roberts, Allan McI. Mowat, R. M. M. Maizels, Georgia Perona‐Wright, Simon W. F. Milling

This study shows that intestinal helminth infection shifts DC2 development towards a regulatory phenotype to suppress anti-helminth immunity.

bioRxiv · Sep 11, 2024 · PreprintImmunology