Edward W. Roberts

CYCLOPS provides an open-source platform for cyclic multiplex imaging and single-cell phenotyping using standard microscopy infrastructure, enabling reproducible and accessible spatial proteomics.

This study shows that Runx1 and Runx2 suppress Wnt/β-catenin-driven mammary tumourigenesis, with combined loss leading to increased tumour development and oncogenic pathway activation.

This study shows that H5N1 viruses' ability to adapt to bovine cells varies across genotypes and time, with key mutations in PB2 playing a role.

This paper introduces a self-supervised learning framework to analyze multiplex immunofluorescence images, revealing novel prognostic spatial patterns in cancer tissues.

This study shows that respiratory viral infection primes lung epithelial cells to enhance antigen presentation, leading to improved T cell responses to subsequent antigens.

This study shows influenza A viruses induce tunnelling nanotube-like structures through apoptosis to spread between cells, evading immune responses.

The paper shows that IFN-gamma-insensitive tumours can still be controlled by immune responses, with IFN-gamma driving myeloid cell remodelling that enhances anti-tumour immunity.

FISHtoFigure is a software tool for analysing smFISH data, enabling automated spatial analysis of mRNA expression without requiring bioinformatics expertise.