Dianbo Liu

CellMemory interprets out-of-distribution cells using a bottlenecked Transformer, outperforming pre-trained models and enabling accurate analysis of spatially resolved single-cell data.

This study develops a high-throughput method to engineer 5' UTRs that enhance protein expression in non-viral gene therapies, identifying synthetic 5 UTRs that outperform existing plasmids.

The paper shows that high gene dosages alter transcriptional regulation of genetic structures, leading to monoallelic expression and cell population heterogeneity, with implications for synthetic biology.

The paper explains a VSG hierarchy in Trypanosoma brucei infections through a growth-rate mechanism linked to VSG length, showing shorter VSGs trigger immune responses while longer VSGs persist due to slower growth.

The paper identifies linear regulatory chains as universal attenuators in gene regulatory networks, showing they dampen expression variation and interact with feedback loops across organisms.