ATXN2 polyglutamine expansion impairs QKI-dependent alternative splicing and oligodendrocyte maintenance
Nesli-Ece Şen, Jaime Eugenin von Bernhardi, Jubril Olamide Adeyemi, Aleksandar Arsović, Júlia Canet-Pons, Antonio J. Miralles, Jana Key, Lorenzo Bina, Vincenzo Romano, Meike Fellenz, Matthias Pietzke, Melanie Vanessa Halbach, Kay Seidel, Elif Fidan, Zeynep Ece Kaya Güleç, , Georg W. J. Auburger
This study shows that ATXN2 polyglutamine expansion impairs QKI-dependent alternative splicing and oligodendrocyte maintenance in a mouse model of SCA2.
bioRxiv · Aug 8, 2025 · PreprintNeuroscience