John B. Bruning

This paper characterizes the structure and inhibition of mannitol-2-dehydrogenase in Aspergillus fumigatus, identifying 1,4-benzoquinone as a potent inhibitor with antifungal activity.

This study characterizes the structure and catalytic mechanism of AfuCys1a, identifies potential inhibitors, and aims to combat antifungal drug resistance in Aspergillus fumigatus.

This study shows asciminib effectively treats NUP214::ABL1 ALL in preclinical models by inhibiting ABL1 kinase and improving survival.

The paper identifies a ternary switch in ERα LBD that regulates receptor activity through distinct H12 conformations, revealing an apo state and its destabilization by mutations.

This paper identifies CymR-derived pentapeptides as nanomolar inhibitors of SaCysK, showing higher potency than CysE-derived peptides.

This study analyzes the structural evolution of estrogen receptor regulatory domains, revealing conserved network structures and their implications for breast cancer and reproductive disorders.

The paper identifies core and flanking DNA interactions in bHLH-PAS transcription factors that determine binding specificity and link to obesity.