Author

Daniel P. McDougal

The University of AdelaideORCID 0000-0003-4499-6789Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

John B. BruningiD· 4 shared Jordan L. PederickiD· 2 shared Adrienne E. SullivaniD· 1 shared Andrew S. MooreiD· 1 shared Annmaree K. WarrenderiD· 1 shared Blagojce Jovcevski‬iD· 1 shared Bruce D. PascaliD· 1 shared Caitlin E Schutz· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersBiochemistry

John B. BruningORCID

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Author profile →

4 papers

Recent·Most cited

Cancer BiologybioRxivPreprintMay 6, 2025

The STAMP inhibitor asciminib is a new treatment option for ABL-rearranged ALL revealing a novel role for the 5' fusion partner in determining drug response

Laura N Eadie, Daniel P. McDougal, Elias Lagonik…·Deborah L. White

This study shows asciminib effectively treats NUP214::ABL1 ALL in preclinical models by inhibiting ABL1 kinase and improving survival.

DOI 10.1101/2025.05.06.652078

mouseexperimental assay

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BiochemistrybioRxivPreprintFeb 9, 2025

A ternary switch determines ERα LBD conformation

Daniel P. McDougal, Jordan L. Pederick, Scott J. Novick…·John B. Bruning

The paper identifies a ternary switch in ERα LBD that regulates receptor activity through distinct H12 conformations, revealing an apo state and its destabilization by mutations.

DOI 10.1101/2025.02.09.637324

humanprotein structure

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BiochemistrybioRxivPreprintDec 18, 2024

Structural evolution of the estrogen receptor regulatory domain

Daniel P. McDougal, Jordan L. Pederick, Linda Shearwin‐Whyatt…·John B. Bruning

This study analyzes the structural evolution of estrogen receptor regulatory domains, revealing conserved network structures and their implications for breast cancer and reproductive disorders.

1 citation

humanstructural biology

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Molecular BiologybioRxivPreprintFeb 1, 2022

Core and Flanking bHLH-PAS:DNA interactions mediate specificity and drive obesity

David C. Bersten, Adrienne E. Sullivan, Daniel P. McDougal…·Murray L. Whitelaw

The paper identifies core and flanking DNA interactions in bHLH-PAS transcription factors that determine binding specificity and link to obesity.

3 citations

mouseDNA methylation

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