Synaptotoxic effects of extracellular tau are mediated by its microtubule-binding region
Tomáš Ondrejčák, Neng‐Wei Hu, Emily Coode, Tom Campbell, Grant T. Corbett, Ivan Doykov, Kevin A. Mills, Dominic M. Walsh, Frederick J. Livesey, Michael J. Rowan, Igor V. Klyubin
This study shows that extracellular tau's synaptotoxic effects are mediated by its microtubule-binding region, and targeting this region can reverse synaptic plasticity disruption.
Acta Neuropathologica · Jun 2, 2025Peer-reviewedNeuroscience