Author

Michael J. Rowan

Trinity College DublinORCID 0000-0002-3867-9536Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:rat· 3 Research Focus:cell-cell communication· 1 Assay:imaging· 1 Assay:proteomics· 1

Frequent Co-Authors

Igor V. KlyubiniD· 2 shared Neng‐Wei HuiD· 2 shared A. Claudio CuelloiD· 1 shared Bo LiiD· 1 shared Daniel JustusiD· 1 shared Detlef Friedrichs· 1 shared Dominic M. WalshiD· 1 shared Emily Coode· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersNeuroscience

Igor V. KlyubinORCID

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3 papers

Recent·Most cited

Synaptotoxic effects of extracellular tau are mediated by its microtubule-binding region

Tomáš Ondrejčák, Neng‐Wei Hu, Emily Coode, Tom Campbell, Grant T. Corbett, Ivan Doykov, Kevin A. Mills, Dominic M. Walsh, Frederick J. Livesey, Michael J. Rowan, Igor V. Klyubin

This study shows that extracellular tau's synaptotoxic effects are mediated by its microtubule-binding region, and targeting this region can reverse synaptic plasticity disruption.

Acta Neuropathologica · Jun 2, 2025Peer-reviewedNeuroscience

LTD-inducing low frequency stimulation enhances p-Tau181 and p-Tau217 in an age-dependent manner in live rats

Yangyang Zhang, Yin Yang, Zhengtao Hu, Manyi Zhu, Shuangying Qin, Pengpeng Yu, Bo Li, Ji‐Tian Xu, Michael J. Rowan, Neng‐Wei Hu

This study shows that low frequency stimulation enhances specific tau phosphorylation sites in aged rats, with potential implications for Alzheimer's disease.

bioRxiv · Mar 28, 2022 · PreprintNeuroscience

Hippocampal hyperactivity in a rat model of Alzheimers disease

Liudmila Sosulina, Manuel Mittag, Hans‐Rüdiger Geis, Kerstin Hoffmann, Igor V. Klyubin, Yingjie Qi, Julia Steffen, Detlef Friedrichs, Niklas Henneberg, Falko Fuhrmann, Daniel Justus, Kevin Keppler, A. Claudio Cuello, Michael J. Rowan, Martin Fuhrmann, Stefan Remy

The paper investigates hippocampal neuronal activity in a rat Alzheimer's disease model, finding hyperactivity and intrinsic excitability changes in CA1 neurons before synaptic inhibition is affected.

Journal of Neurochemistry · Feb 14, 2021Peer-reviewedNeuroscience