Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism
Yi Kuang, Ohad Golan, Kristina Preuße, Brittany Cain, Collin J Christensen, Joseph R. Salomone, Ian Campbell, FearGod V Okwubido-Williams, Matthew R. Hass, Zhenyu Yuan, Natanel Eafergan, Kenneth H. Moberg, Rhett A. Kovall, Raphael Kopan, David Sprinzak, Brian A. Gebelein
The paper shows that an enhancer with specific binding sites can induce Notch haploinsufficiency phenotypes in Drosophila with wild-type Notch gene dose by promoting rapid Notch turnover through a bind and discard mechanism.
eLife · Apr 16, 2020Peer-reviewedDevelopmental Biology