Joseph R. Salomone

Gli3 utilizes Hand2 to synergistically regulate tissue-specific transcriptional networks

This study shows Gli3 and Hand2 work together to control gene expression in craniofacial development without relying on a graded Hh signal.

Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism

The paper shows that an enhancer with specific binding sites can induce Notch haploinsufficiency phenotypes in Drosophila with wild-type Notch gene dose by promoting rapid Notch turnover through a bind and discard mechanism.

Physical interactions between Gsx2 and Ascl1 regulate the balance between progenitor expansion and neurogenesis in the mouse lateral ganglionic eminence

The paper shows that Gsx2 and Ascl1 physically interact in the mouse lateral ganglionic eminence, inhibiting Ascl1-driven neurogenesis and promoting progenitor expansion.

The cis-regulatory logic underlying abdominal Hox-mediated repression versus activation of regulatory elements in Drosophila

This study investigates how abdominal Hox factors regulate distinct cis-regulatory elements in Drosophila by comparing activation and repression mechanisms.