Author

Ruth C. E. Bowyer

King's College LondonORCID 0000-0002-6941-8160Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 3 Bioinformatics· 1 Genetics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 5 Research Focus:GWAS / association mapping· 3 Assay:bulk RNA-seq· 2 Assay:GWAS summary statistics· 2 Assay:metabolomics· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Claire Joanne StevesiD· 6 shared Cristina MenniiD· 3 shared Massimo ManginoiD· 3 shared Tim D. SpectoriD· 3 shared Kerrin S. SmalliD· 2 shared Maxim B. FreidiniD· 2 shared Abhishek NagiD· 1 shared Alessandro MoreaiD· 1 shared

Activity by Year

2020-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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6 shared papersGenetic & Genomic Medicine

Claire Joanne StevesORCID

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Exploring the genetic architecture of multimorbidity and its impact on long COVID risk

Sasha J. M. Bauer, Ruth C. E. Bowyer, Laura Bravo-Merodio, GEORGIOS GKOUTOS, Davide Vetrano, Thomas Jackson, Claire Joanne Steves, Maxim B. Freidin

This study identifies multimorbidity clusters and their genetic architecture but finds no significant genetic overlap with long COVID.

medRxiv · May 22, 2026 · PreprintGenetic & Genomic Medicine

ESPClust: Unsupervised identification of modifiers for the effect size profile in omics association studies

Francisco J. Pérez‐Reche, Nathan J. Cheetham, Ruth C. E. Bowyer, Ellen J. Thompson, Francesca Tettamanzi, Cristina Menni, Claire Joanne Steves

ESPClust identifies covariates modifying effect sizes in omics association studies, revealing subpopulations with distinct associations.

Bioinformatics · Feb 1, 2025Peer-reviewedBioinformatics

Age acquired skewed X Chromosome Inactivation is associated with adverse health outcomes in humans

Amy L. Roberts, Alessandro Morea, Ariella Amar, Antonino Zito, Julia S. El-Sayed Moustafa, Max Tomlinson, Ruth C. E. Bowyer, Xinyuan Zhang, Colette Christiansen, Ricardo Costeira, Claire Joanne Steves, Massimo Mangino, Jordana T. Bell, Chloe C. Y. Wong, Timothy James Vyse, Kerrin S. Small

This study shows that age-related skewed X chromosome inactivation in females is linked to increased cardiovascular disease risk and cancer incidence.

eLife · Nov 1, 2022Peer-reviewedGenetic & Genomic Medicine

Self-reported symptoms of covid-19 including symptoms most predictive of SARS-CoV-2 infection, are heritable

Frances M. K. Williams, Maxim B. Freidin, Massimo Mangino, Simon Couvreur, Alessia Visconti, Ruth C. E. Bowyer, Caroline Ivanne Le Roy, Mario Falchi, Olatz Mompeó, Carole H. Sudre, Richard Davies, Christopher J. Hammond, Cristina Menni, Claire Joanne Steves, Tim D. Spector

The paper identifies heritable symptoms of SARS-CoV-2 infection using twin studies of self-reported symptoms from the TwinsUK cohort.

Twin Research and Human Genetics · Dec 1, 2020Peer-reviewedGenetic & Genomic Medicine

Introducing ExHiBITT - Exploring Host microbiome inTeractions in Twins-, a colon multiomic cohort study

Marina Mora-Ortiz, Hajir Ibraheim, Sherine Hermangild Kottoor, Ruth C. E. Bowyer, Sarah Metrustry, Jeremy David Sanderson, Nick Powell, Tim D. Spector, Kerrin S. Small, Claire Joanne Steves

The paper introduces ExHiBITT, a colon multiomic cohort study of twins, describing its characteristics and initial findings on polyps, diverticulosis, and their associations with BMI and age.

Wellcome Open Research · Feb 13, 2020Peer-reviewedSystems Biology

Genome-wide scan identifies novel genetic loci regulating salivary metabolite levels

Abhishek Nag, Yuko Kurushima, Ruth C. E. Bowyer, Philippa M. Wells, Stefan Weiß, Maik Pietzner, Thomas Kocher, Johannes Raffler, Uwe Völker, Massimo Mangino, Tim D. Spector, Michael V. Milburn, Gabi Kastenmüller, Robert P. Mohney, Karsten Suhre, , Claire Joanne Steves

This study identifies 11 genetic loci associated with salivary metabolites in 1,419 individuals, revealing novel saliva-specific associations and potential clinical applications.

Human Molecular Genetics · Jan 17, 2020Peer-reviewedGenetics